The secondary antagonist of the series, Mrs. Brinks is an eccentric middle-aged woman who is a dedicated third grade teacher with a rather masculine voice (rather, sounding more like a man imitating a woman) and large manly hands. She wears a huge grey beehive wig which hides her short ginger hair, and she dresses in a long-skirted schoolmarm dress, hiding her old figure. Although she’s not a bad teacher, she’s easily manipulated and plays favorites, her decisions always favoring Nanette, whom she sees as the perfect little girl, although there have been moments when Nanette has gotten in trouble with her. Unfortunately, Mrs. Brinks is biased against Angela and is very strict and callous with her (making her the second least favorite character on the show), though in the episode "Jiggly Fruit Classic" she and Angela overcome their differences in order to get old Jiggly Fruit back. Mrs. Brinks likes to believe she's sophisticated and succumbs easily to flattery. She thinks Angela is a bizarre, troublemaking and wayward girl, and constantly punishes her for things she didn't do by making her clap the chalkboard erasers (something Angela has since become very good at) among other punishments. However, Mrs. Brinks made Angela the top of her class when she believes Angela's poem about her dog is about her [Brinks] in the episode "You're So Vain". She and her frail, generous, and long-suffering husband, Conrad Brinks are rumored to be weekend nudists. Angela and her gang often peer into the Brinks' backyard from Angela's tree house to find out if this rumor is true, though the show only shows Angela and her friend's reactions to what they see (later, the rumor is confirmed when Angela tricks Nanette into going in to the backyard). In "Brinks of No Return", Mr. Brinks reveals that he and Mrs. Brinks used to have a very loving relationship before Nanette came into her life. In the episode "Earhart's Heirloom" she claims to have the compass of Amelia Earhart and promises to show it to the class but only if they behave for 30 days running (it is later revealed that the compass was made in Taiwan in 1995 and it was all a scam to get the class to behave). It is revealed in the episode "The Bird Lady of Tapwater Springs" that she has an artificial hip which prevented her from dancing. In the episode "The Great Granny Grudge", it is revealed that her husband Conrad Brinks used to go out with Johnny and Angela's grandmothers.
- Mrs. Brinks is voiced by Richard Binsley.
- She took her class to the space museum in the episode 'Rat Heroes'.
- She blatantly favours Nanette Manoir, implicitly because Nanette is the daughter of a rich family, and so almost always takes her side against Angela's.